张竹青,女, 中国科学院大学生命科学学院副教授、硕导,九三学社社员。
研究领域
主要研究方向为生物大分子构象变化相关的计算机模拟工作,包括蛋白质折叠,错误折叠,蛋白质-蛋白质,蛋白质-DNA的相互作用等。
教育背景
2000.09--2005.06 中国科学院化学所 博士
1995.09--2000.07 北京化工大学 学士
工作经历
2005-2007 北京大学化学与分子工程学院,理论生物中心,博士后
2008-2011 加拿大多伦多大学医学院生物化学系,博士后
2011.6-现在 中国科学院研究生院生命科学学院 副教授
代表性论文
1. Zhuqing Zhang, and Hue Sun Chan. "Transition paths, diffusive processes, and preequilibria of protein folding". Proc Natl Acad Sci U S A. 2012: 109: 20919-20924
2. Zarrine-Afsar* A., Zhang* Z., Schweiker KL., Makhatadze GI., Davidson AR. and Chan HS. “Kinetic Consequences of Native State Optimization of Surface-Exposed Electrostatic Interactions in the Fyn SH3 Domain”. Proteins: Structure, Function, and Bioinformatics (2012) 80: 858-870 (*equal contribution)
3. Hue Sun Chan, Zhuqing Zhang, Stefan Wallin and Zhirong Liu. “Native Topology, Local-Nonlocal Coupling, and Nonnative Interactions: Principles of Protein Folding from Coarse-Grained Models”. Annu Rew Phys Chem. 2011: 62: 301-32
4. Zhuqing Zhang, and Hue Sun Chan. “Competition between Native Topology and Nonnative Interactions in Simple and Complex Folding Kinetics of Natural and Designed Proteins”. Proc Natl Acad Sci U S A. 2010: 107: 2920–2925
5. Zhuqing Zhang and Hue Sun Chan. “Native Topology of the Designed Protein Top7 is not Conducive to Cooperative Folding”. Biophys J. 2009: 96: L25-L27
6. Zhuqing Zhang, Hao Chen, Luhua Lai. “Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential”. Bioinformatics. 2007: 23: 2218-2225
7. Zhuqing Zhang, Hao Chen, Hongjun Bai, Luhua Lai. “Molecular dynamics simulations on the oligomer formation process of the GNNQQNY peptide from yeast prion protein Sup35”. Biophys J. 2007; 93; 1484-1492
科研项目
1.北京分子国家实验室开放课题基金,主持,研究所(学校)级,2011-11--2013-11
2.院长基金B,主持,院级级,2011-07--2013-04